Cdc20 antibody

Product Name Cdc20 antibody

Catalog No PAab09997

Packing 100ul

Form liquid

Alternative Name CDC20, CDC20A, p55CDC

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome(APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Immunogen cell division cycle 20 homolog

Specificity Human

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:500-1:2000; IHC: 1:20-1:200

IHC use Immunohistochemistry of paraffin-embedded human colon cancer using PAab09997(CDC20 antibody) at dilution of 1:100

WB use

HeLa cells were subjected to SDS PAGE followed by western blot with PAab09997(CDC20 antibody) at dilution of 1:1000

Protein Information

Gene ID 991

Uniprot ID Q12834

Calculated MW 55 kDa

Research Area Cell Division and Proliferation, Metabolism