MAP3K1 antibody

Product Name MAP3K1 antibody

Catalog No PAab10071

Packing 100ul

Form liquid

Alternative Name MAP3K1, MAPK/ERK kinase kinase 1, MAPKKK1, MEK kinase 1, MEKK, MEKK 1, MEKK1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

MAP3K1, also named as MAPKKK1, MEKK and MEKK1, belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase kinase subfamily. MAP3K1 is a component of a protein kinase signal transduction cascade. MAP3K1 activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. It activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. It catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein.

Immunogen mitogen-activated protein kinase kinase kinase 1

Specificity Human

Tested Application ELISA, IHC

Recommended dilution IHC: 1:20-1:200

IHC use Immunohistochemistry of paraffin-embedded human colon cancer using PAab10071( MAP3K1 Antibody) at dilution of 1:100

WB use

Protein Information

Gene ID 4214

Uniprot ID Q13233

Calculated MW 164 kDa

Research Area Immunology, Metabolism