P62/SQSTM1 antibody

Product Name P62/SQSTM1 antibody

Catalog No PAab09853

Packing 100ul

Form liquid

Alternative Name P62, sequestosome 1, SQSTM1, Ubiquitin binding protein p62

Purification protein A+G purified

Purity 95% as determined by SDS-PAGE

Host mouse

Isotype IgG2a

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Immunogen sequestosome 1

Specificity Human, Mouse

Tested Application ELISA, WB, IHC, IF

Recommended dilution WB: 1:1000 - 1:4000; IHC: 1:50 - 1:500; IF: 1:20 - 1:200

IHC use Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using PAab09853(SQSTM1 Antibody) at dilution of 1:100

WB use

HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab09853(SQSTM1 antibody) at dilution of 1:2000

Protein Information

Gene ID 8878

Uniprot ID Q13501

Calculated MW 25 kDa

Research Area Neuroscience, Cardiovascular, Metabolism, Signal Transduction