PTCH1 antibody

Product Name PTCH1 antibody

Catalog No PAab10084

Packing 100ul

Form liquid

Alternative Name HPE7, NBCCS, Patched, patched homolog 1, Patched1, Protein patched homolog 1, PTC, PTC1, PTCH, PTCH1, PTCH11

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Acts as a receptor for sonic hedgehog(SHH), indian hedgehog(IHH) and desert hedgehog(DHH). Associates with the smoothened protein(SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

Immunogen patched homolog 1

Specificity Human, Rat

Tested Application ELISA, IHC

Recommended dilution IHC: 1:20-1:200

IHC use Immunohistochemistry of paraffin-embedded human colon cancer using PAab10084(PTCH1 antibody) at dilution of 1:50

WB use

Protein Information

Gene ID 5727

Uniprot ID Q13635

Calculated MW 161 kDa

Research Area Neuroscience, Cell Division and Proliferation