STAT1 antibody

Product Name STAT1 antibody

Catalog No PAab09985

Packing 100ul

Form liquid

Alternative Name ISGF 3, STAT1, STAT91

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Signal transducer and transcription activator that mediates cellular responses to interferons(IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN(IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases(TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of IFN-stimulated genes(ISG), which drive the cell in an antiviral state. In response to type II IFN(IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor(GAF), migrates into the nucleus and binds to the IFN gamma activated sequence(GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

Immunogen signal transducer and activator of transcription 1, 91kDa

Specificity Human, Rat

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:500

IHC use Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab09985(STAT1 Antibody) at dilution of 1:200

WB use

Rat liver tissue were subjected to SDS PAGE followed by western blot with PAab09985(STAT1 antibody) at dilution of 1:1000

Protein Information

Gene ID 6772

Uniprot ID P42224

Calculated MW 84 kDa

Research Area Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology