Anti-BCL2 antibody

Product Name Anti-BCL2 antibody

Catalog No PAab00840

Packing 100ug

Form liquid

Alternative Name

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG2a

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

Immunogen B-cell CLL/lymphoma 2

Specificity Human

Tested Application ELISA,WB,FC,IP,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using BCL2 Antibody at dilution of 1:100

WB use

Jurkat cells were subjected to SDS PAGE followed by western blot with PAab00840( BCL2 Antibody) at dilution of 1:4000

Protein Information

Gene ID12043

Uniprot ID P10415

Calculated MW

location