Anti-NR1H3 antibody
Product Name Anti-NR1H3 antibody
Catalog No PAab05836
Packing 100ug
Form liquid
Alternative Name LXRA
Purification Protein A+G purification
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG2a
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
Immunogen nuclear receptor subfamily 1, group H, member 3
Specificity Human, Rat
Tested Application ELISA,WB,IF
Recommended dilution
IHC use
WB use
Protein Information
Gene ID10062
Uniprot ID Q13133
Calculated MW
location