Anti-RENALASE antibody

Product Name Anti-RENALASE antibody

Catalog No PAab07239

Packing 100ug

Form liquid

Alternative Name C10orf59 antibody, MAO C antibody, Monoamine oxidase C antibody, RENALASE antibody, RNLS

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity. (PMID:15841207 ) This antibody is specific to RNLS.

Immunogen chromosome 10 open reading frame 59

Specificity Human

Tested Application ELISA,WB,IHC

Recommended dilution WB:1:1000-1:10000;IHC:1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human kidney using RENALASE Antibody at dilution of 1:100

WB use

human heart tissue were subjected to SDS PAGE followed by western blot with PAab07239(RENALASE antibody) at dilution of 1:2000

Protein Information

Gene ID55328

Uniprot ID Q5VYX0

Calculated MW 38kDa

location