Anti-MAP3K3 antibody

Product Information

Product Name: Anti-MAP3K3 antibody

Catalog No.: LSMab09784

Packing: 100ug

Form: liquid

Purity:more than 95% as determined by SDS-PAGE

Purification: Immunogen affinity purified

Host: Rabbit

Isotype: IgG

Storage Condition: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20degrees for 24 months(Avoid repeated freeze / thaw cycles.)

Immunogen Information

Immunogen Name:mitogen-activated protein kinase kinase kinase 3

Background: The mitogen-activated protein/ERK kinase kinase 3(MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.

Synonyms: MAP3K3, MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK 3, MEKK3

Calculated MW: 113 kDa

Uniprot ID: Q99759

Gene ID: 4215

Validation

Specificity: Human

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:200-1:1000; IHC: 1:50-1:500

IHC use: Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using LSMab09784(MAP3K3 Antibody) at dilution of 1:100

WB use: mouse liver tissue were subjected to SDS PAGE followed by western blot with LSMab09784(MAP3K3 Antibody) at dilution of 1:300

Caution:

1. Product is used for research only!