Anti-AATF antibody

Product Name Anti-AATF antibody

Catalog No PAab00025

Packing 100ug

Form liquid

Alternative Name AATF antibody, CHE 1 antibody, CHE1 antibody, DED antibody, Protein AATF antibody, Rb binding protein Che 1 antibody, Traube

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Immunogen apoptosis antagonizing transcription factor

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IF

Recommended dilution WB : 1:200-1:2000;IF:1:10-1:100

IHC use

WB use

mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab00025(AATF antibody) at dilution of 1:800

Protein Information

Gene ID26574

Uniprot ID Q9NY61

Calculated MW 63kDa

location