Anti-Alpha B Crystallin antibody
Product Name Anti-Alpha B Crystallin antibody
Catalog No PAab00325
Packing 100ug
Form liquid
Alternative Name Alpha B Crystallin antibody, Alpha crystallin B chain antibody, Alpha(B) crystallin antibody, CRYA2 antibody, CRYAB antibody, crystallin antibody, alpha B antibody, CTPP2 antibody, Heat shock protein beta 5 antibody, HSPB5 antibody, Rosenthal fiber component
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Alpha B-crystallin, encoded by CRYAB gene, is multifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.
Immunogen crystallin, alpha B
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IHC,IP
Recommended dilution WB :1:500-1:5000;IHC:1:20-1:200;IP:1:200-1:2000
IHC use
Immunohistochemistry of paraffin-embedded human eye usingCRYAB antibody at dilution of 1:100
WB use
human heart tissue were subjected to SDS PAGE followed by western blot with PAab00325(CRYAB antibody) at dilution of 1:500
Protein Information
Gene ID1410
Uniprot ID P02511
Calculated MW 20kDa
location