Anti-Amphiphysin antibody

Product Name Anti-Amphiphysin antibody

Catalog No PAab00373

Packing 100ug

Form liquid

Alternative Name Amphiphysin antibody,AMPH1 antibody,AMPH

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Amphiphysin (AMPH), a synaptic vesicle-associated protein that is highly concentrated in nerve terminal, is an autoantigen of Stiff-Man syndrome with breast cancer. Amphiphysin contains a N-terminal BAR (Bin1/Amphiphysin/Rv167) domain followed by an endocytosis domain, and a C-terminal SH3 domain. Amphiphysin has been proposed to function as a linker between the clathrin coat and dynamin in the endocytosis of synaptic vesicles. It may also participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. (PMID: 8552632; 8245793; 10559861)

Immunogen amphiphysin

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC,IP

Recommended dilution WB :1:500-1:5000;IHC:1:20-1:200;IP:1:500-1:5000

IHC use

Immunohistochemistry of paraffin-embedded human pancreas cancer usingAMPH antibody at dilution of 1:100

WB use

mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab00373(AMPH antibody) at dilution of 1:1500

Protein Information

Gene ID273

Uniprot ID P49418

Calculated MW 76kDa,observed 120kDa

location