Product Name Anti-BACE1 antibody
Catalog No PAab00781
Alternative Name BACE antibody, KIAA1149
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Immunogen beta-site APP-cleaving enzyme 1
Specificity Human, Mouse , Zebrafish
Tested Application ELISA,WB,IP,IHC
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using BACE1 Antibody at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA bufferpH9).
mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab00781(BACE1 antibody) at dilution of 1:500
Uniprot ID P56817