Anti-BBS5 antibody

Product Name Anti-BBS5 antibody

Catalog No PAab00819

Packing 100ug

Form liquid

Alternative Name

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

Immunogen Bardet-Biedl syndrome 5

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IF,IHC,IP

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human testis tissue slide using BBS5 Antibody at dilution of 1:200

WB use

mouse testis tissue were subjected to SDS PAGE followed by western blot with PAab00819(BBS5 antibody) at dilution of 1:400

Protein Information

Gene ID129880

Uniprot ID Q8N3I7

Calculated MW

location