Anti-Beclin 1 antibody

Product Name Anti-Beclin 1 antibody

Catalog No PAab00860

Packing 100ug

Form liquid

Alternative Name ATG6 antibody, Beclin 1 antibody, beclin 1 antibody, autophagy related antibody, beclin1 antibody, BECN1 antibody, GT197 antibody, Protein GT197 antibody, VPS30

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.

Immunogen beclin 1, autophagy related

Specificity Human, Mouse ,Rat

Tested Application ELISA,IHC,IP,WB,IF

Recommended dilution WB:1:500-1:5000;IP:1:200-1:2000;IHC:1:20-1:200;IF:1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human colon cancer usingBeclin 1 antibody at dilution of 1:50

WB use

MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with PAab00860( Beclin 1 Antibody) at dilution of 1:1000

Protein Information

Gene ID8678

Uniprot ID Q14457?

Calculated MW 60kDa

location