Anti-BLNK antibody

Product Name Anti-BLNK antibody

Catalog No PAab00908

Packing 100ug

Form liquid

Alternative Name BASH antibody, SLP65

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

Immunogen B-cell linker

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using BLNK Antibody at dilution of 1:400 heat mediated antigen retrieved with Tris-EDTA bufferpH9).

WB use

Raji cells were subjected to SDS PAGE followed by western blot with PAab00908( BLNK Antibody) at dilution of 1:1000

Protein Information

Gene ID29760

Uniprot ID Q8WV28

Calculated MW

location