Product Name Anti-BLNK antibody
Catalog No PAab00908
Alternative Name BASH antibody, SLP65
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Immunogen B-cell linker
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IHC
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using BLNK Antibody at dilution of 1:400 heat mediated antigen retrieved with Tris-EDTA bufferpH9).
Raji cells were subjected to SDS PAGE followed by western blot with PAab00908( BLNK Antibody) at dilution of 1:1000
Uniprot ID Q8WV28