Anti-DIS3 antibody
Product Name Anti-DIS3 antibody
Catalog No PAab02394
Packing 100ug
Form liquid
Alternative Name KIAA1008 antibody, RRP44
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
Immunogen DIS3 mitotic control homolog (S. cerevisiae)
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IHC
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human ovary tumor usingDIS3 antibody at dilution of 1:100
WB use
HeLa cells were subjected to SDS PAGE followed by western blot with PAab02394(DIS3 antibody) at dilution of 1:500
Protein Information
Gene ID22894
Uniprot ID Q9Y2L1
Calculated MW
location