Anti-EIF2AK3 antibody
Product Name Anti-EIF2AK3 antibody
Catalog No PAab02692
Packing 100ug
Form liquid
Alternative Name PEK antibody, PERK
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)- induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Immunogen eukaryotic translation initiation factor 2-alpha kinase 3
Specificity Human
Tested Application ELISA,IHC,WB
Recommended dilution
IHC use
Immunofluorescent analysis of A431 cells using ELOVL4 Antibody at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgGH+L)
WB use
Y79 cells were subjected to SDS PAGE followed by western blot with PAab02692(ELOVL4 antibody) at dilution of 1:500
Protein Information
Gene ID9451
Uniprot ID Q9NZJ5
Calculated MW
location