Anti-EIF4EBP2 antibody

Product Name Anti-EIF4EBP2 antibody

Catalog No PAab02723

Packing 100ug

Form liquid

Alternative Name

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).

Immunogen eukaryotic translation initiation factor 4E binding protein 2

Specificity Human, Mouse

Tested Application ELISA,IHC,WB

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human prostate cancer usingEIF4EBP2 antibody at dilution of 1:100

WB use

mouse testis tissue were subjected to SDS PAGE followed by western blot with PAab02723( EIF4EBP2 Antibody) at dilution of 1:300

Protein Information

Gene ID1979

Uniprot ID Q13542

Calculated MW

location