Anti-IA-2/PTPRN antibody

Product Name Anti-IA-2/PTPRN antibody

Catalog No PAab04092

Packing 100ug

Form liquid

Alternative Name

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family, which contains a transmembrane region, an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.

Immunogen protein tyrosine phosphatase, receptor type, N

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB,IHC,IP

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human pancreas cancer usingPTPRN antibody at dilution of 1:50

WB use

mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab04092(PTPRN antibody) at dilution of 1:300

Protein Information

Gene ID5798

Uniprot ID   Q16849

Calculated MW 105 kDa

location  Plasma membranel; Endosome