Anti-INSIG2 antibody

Product Name Anti-INSIG2 antibody

Catalog No PAab04334

Packing 100ug

Form liquid

Alternative Name

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.

Immunogen insulin induced gene 2

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB,IHC,IF

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human liver tissue slide using INSIG2 Antibody at dilution of 1:50

WB use

rat liver tissue were subjected to SDS PAGE followed by western blot with PAab04334( INSIG2 Antibody) at dilution of 1:1000

Protein Information

Gene ID51141

Uniprot ID Q9Y5U4

Calculated MW

location