Anti-ITM2C antibody

Product Name Anti-ITM2C antibody

Catalog No PAab04418

Packing 100ug

Form liquid

Alternative Name BRI3

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).

Immunogen integral membrane protein 2C

Specificity Human

Tested Application ELISA,WB,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human colon tissue slide using ITM2C Antibody at dilution of 1:50

WB use

Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab04418( ITM2C Antibody) at dilution of 1:1000

Protein Information

Gene ID81618

Uniprot ID Q9NQX7

Calculated MW

location