Anti-LATS1 antibody
Product Name Anti-LATS1 antibody
Catalog No PAab04708
Packing 100ug
Form liquid
Alternative Name WARTS
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Immunogen LATS, large tumor suppressor, homolog 1 (Drosophila)
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IHC
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human testis tissue slide using LATS1 Antibody at dilution of 1:50
WB use
mouse testis tissue were subjected to SDS PAGE followed by western blot with PAab04708(LATS1 antibody) at dilution of 1:500
Protein Information
Gene ID9113
Uniprot ID O95835
Calculated MW
location