Anti-NAT10 antibody

Product Name Anti-NAT10 antibody

Catalog No PAab05562

Packing 100ug

Form liquid

Alternative Name ALP antibody, KIAA1709

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003).

Immunogen N-acetyltransferase 10 (GCN5-related)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IF,IP

Recommended dilution

IHC use

WB use

Protein Information

Gene ID55226

Uniprot ID Q9H0A0

Calculated MW

location