Anti-NFKBIZ antibody
Product Name Anti-NFKBIZ antibody
Catalog No PAab05709
Packing 100ug
Form liquid
Alternative Name IKBZ antibody, INAP antibody, MAIL
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).
Immunogen nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB
Recommended dilution
IHC use
WB use
Protein Information
Gene ID64332
Uniprot ID Q9BYH8
Calculated MW
location