Anti-NOTCH3 antibody

Product Name Anti-NOTCH3 antibody

Catalog No PAab05800

Packing 100ug

Form liquid

Alternative Name

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).

Immunogen Notch homolog 3 (Drosophila)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC,IP

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using NOTCH3 Antibody at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA bufferpH9).

WB use

COLO 320 cells were subjected to SDS PAGE followed by western blot with PAab05800(NOTCH3 antibody) at dilution of 1:500

Protein Information

Gene ID4854

Uniprot ID Q9UM47

Calculated MW

location