Anti-NR5A1 antibody

Product Name Anti-NR5A1 antibody

Catalog No PAab05847

Packing 100ug

Form liquid

Alternative Name AD4BP antibody, FTZF1 antibody, SF1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

Immunogen nuclear receptor subfamily 5, group A, member 1

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC,IP

Recommended dilution WB:1:500-1:5000;IP:1:200-1:1000;IHC:1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human liver usingNR5A1 antibody at dilution of 1:100

WB use

mouse ovary tissue were subjected to SDS PAGE followed by western blot with PAab05847(NR5A1 antibody) at dilution of 1:1000

Protein Information

Gene ID2516

Uniprot ID Q13285

Calculated MW 52kDa

location