Anti-NTHL1 antibody

Product Name Anti-NTHL1 antibody

Catalog No PAab05883

Packing 100ug

Form liquid

Alternative Name NTH1 antibody, OCTS3

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Immunogen nth endonuclease III-like 1 (E. coli)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human gliomas usingNTHL1 antibody at dilution of 1:50

WB use

Y79 cells were subjected to SDS PAGE followed by western blot with PAab05883(NTHL1 antibody) at dilution of 1:1000

Protein Information

Gene ID4913

Uniprot ID P78549

Calculated MW

location