Product Name Anti-Nurr1/NR4A2 antibody
Catalog No PAab05936
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
NR4A2 belongs to the orphan nuclear receptor (NR) family referred to as NR4A family, which have been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis [PMID:22583411]. NR4A2 also has a role in the expression of several proteins that are necessary for the synthesis and regulation of dopamine (DA), such as tyrosine hidroxilase, dopamine transporter, vesicular monoamine transporter 2, and cRET [PMID:22294735]. Act as a transcriptional regulator, NR4A2 is essential for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons [PMID: 17184956].
Immunogen nuclear receptor subfamily 4, group A, member 2
Tested Application ELISA,IHC
Recommended dilution WB : 1:500-1:1000 IHC : 1:50-1:500 IF : 1:50-1:500
Immunohistochemistry of paraffin-embedded human gliomas tissue slide using Anti-Nurr1/NR4A2 antibody at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
fetal human brain tissue were subjected to SDS PAGE followed by western blot with Anti-Nurr1/NR4A2 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours
Calculated MW 66 kDa