Anti-OAS2 antibody
Product Name Anti-OAS2 antibody
Catalog No PAab05951
Packing 100ug
Form liquid
Alternative Name
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
Immunogen 2'-5'-oligoadenylate synthetase 2, 69/71kDa
Specificity Human, Mouse
Tested Application ELISA,WB,IHC,IF,IP
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human breast cancer usingOAS2 antibody at dilution of 1:50
WB use
Jurkat cells were subjected to SDS PAGE followed by western blot with PAab05951(OAS2 antibody) at dilution of 1:500
Protein Information
Gene ID4939
Uniprot ID P29728
Calculated MW
location