Anti-OPTN antibody
Product Name Anti-OPTN antibody
Catalog No PAab05999
Packing 100ug
Form liquid
Alternative Name FIP2 antibody, GLC1E antibody, HIP7 antibody, HYPL antibody, NRP
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Immunogen optineurin
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IHC,IF,IP
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human gliomas tissue slide using OPTN Antibody at dilution of 1:200
WB use
HeLa cells were subjected to SDS PAGE followed by western blot with PAab05999(OPTN antibody) at dilution of 1:800
Protein Information
Gene ID10133
Uniprot ID Q96CV9
Calculated MW
location