Anti-OSBP antibody
Product Name Anti-OSBP antibody
Catalog No PAab06016
Packing 100ug
Form liquid
Alternative Name OSBP1
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).
Immunogen oxysterol binding protein
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IHC,IP
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human ovary tumor usingOSBP antibody at dilution of 1:50
WB use
HeLa cells were subjected to SDS PAGE followed by western blot with PAab06016(OSBP antibody) at dilution of 1:800
Protein Information
Gene ID5007
Uniprot ID P22059
Calculated MW
location