Anti-P16-INK4A antibody

Product Name Anti-P16-INK4A antibody

Catalog No PAab06064

Packing 100ug

Form liquid

Alternative Name ARF antibody,CDKN2A antibody, CDK4 inhibitor p16 INK4 antibody, CDK4 inhibitor p16INK4 antibody, CDK4I antibody, CDKN2 antibody, CDKN2A antibody, CMM2 antibody, INK4 antibody, INK4a antibody, MLM antibody, MTS 1 antibody, MTS1 antibody, Multiple tumor suppressor 1 antibody, p14 antibody, p14ARF antibody, P16 antibody, p16 INK4 antibody, p16 INK4a antibody, p16INK4 antibody, p16INK4a antibody, P19 antibody, TP16

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively-spliced variants encoding distinct proteins have been reported, and two are related, named p16-INK4 and p14 respetively, sharing 50% identity. The third one is completely stuctually un-related, called p14(ARF) or p19(ARF). 10883-1-AP reacted with p16 specifically. P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers, notably melanoma.

Immunogen cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IF,IP,IHC,FC

Recommended dilution WB:1:500-1:5000;IP:1:500-1:5000;IHC:1:50-1:500;IF:1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using P16-INK4A Antibody at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA bufferpH9).

WB use

HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab06064(P16 antibody) at dilution of 1:1000

Protein Information

Gene ID1029

Uniprot ID P42771

Calculated MW 16kDa

location