Anti-P21 CDKN1A antibody

Product Name Anti-P21 CDKN1A antibody

Catalog No PAab06067

Packing 100ug

Form liquid

Alternative Name CAP20 antibody, CDK interacting protein 1 antibody, CDKN1 antibody, CDKN1A antibody, CIP1 antibody, MDA 6 antibody, MDA6 antibody, P21 antibody, p21CIP1 antibody, PIC1 antibody, SDI1 antibody, WAF1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

CDKN1A (p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.

Immunogen cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Specificity Human,Mouse ,Rat

Tested Application ELISA,IHC,IF,WB

Recommended dilution WB:1:500-1:5000;IP:1:200-1:1000;IHC:1:50-1:500;IF:1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human kidney usingP21 antibody at dilution of 1:50

WB use

HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab06067(P21 antibody) at dilution of 1:500

Protein Information

Gene ID1026

Uniprot ID P38936

Calculated MW 21kDa

location