Anti-PAN2 antibody

Product Name Anti-PAN2 antibody

Catalog No PAab06131

Packing 100ug

Form liquid

Alternative Name KIAA0710 antibody, USP52

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Immunogen PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human heart usingPAN2 antibody at dilution of 1:50

WB use

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with PAab06131(PAN2 antibody) at dilution of 1:300

Protein Information

Gene ID9924

Uniprot ID Q504Q3

Calculated MW

location