Anti-PARD3 antibody

Product Name Anti-PARD3 antibody

Catalog No PAab06146

Packing 100ug

Form liquid

Alternative Name PAR3 antibody, PAR3A

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

Immunogen par-3 partitioning defective 3 homolog (C. elegans)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC,FC,IP

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human colon cancer usingPARD3 antibody at dilution of 1:50

WB use

MCF7 cells were subjected to SDS PAGE followed by western blot with PAab06146(PARD3 antibody) at dilution of 1:300

Protein Information

Gene ID56288

Uniprot ID Q8TEW0

Calculated MW

location