Anti-PARP3 antibody

Product Name Anti-PARP3 antibody

Catalog No PAab06158

Packing 100ug

Form liquid

Alternative Name ADPRT3 antibody, ADPRTL3

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Immunogen poly (ADP-ribose) polymerase family, member 3

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB,IHC,IF

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human pancreas cancer usingPARP3 antibody at dilution of 1:50

WB use

human kidney tissue were subjected to SDS PAGE followed by western blot with PAab06158(PARP3 antibody) at dilution of 1:500

Protein Information

Gene ID10039

Uniprot ID Q9Y6F1

Calculated MW

location