Anti-PDK1 antibody

Product Name Anti-PDK1 antibody

Catalog No PAab06275

Packing 100ug

Form liquid

Alternative Name PDHK1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

Immunogen pyruvate dehydrogenase kinase, isozyme 1

Specificity Human, Mouse

Tested Application ELISA,IHC,WB,IP

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human liver usingPDK1 antibody at dilution of 1:50

WB use

mouse liver tissue were subjected to SDS PAGE followed by western blot with PAab06275( PDK1 Antibody) at dilution of 1:2000

Protein Information

Gene ID5163

Uniprot ID Q15118

Calculated MW

location