Anti-PMEPA1 antibody
Product Name Anti-PMEPA1 antibody
Catalog No PAab06569
Packing 100ug
Form liquid
Alternative Name STAG1 antibody, TMEPAI
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).
Immunogen prostate transmembrane protein, androgen induced 1
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IHC,IF
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human prostate hyperplasia usingPMEPA1 antibody at dilution of 1:50
WB use
L02 cells were subjected to SDS PAGE followed by western blot with PAab06569( PMEPA1 Antibody) at dilution of 1:600
Protein Information
Gene ID56937
Uniprot ID Q969W9
Calculated MW
location