Anti-PSME3 antibody

Product Name Anti-PSME3 antibody

Catalog No PAab06896

Packing 100ug

Form liquid

Alternative Name

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

Immunogen proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC,IF,IP

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human colon cancer usingPSME3 antibody at dilution of 1:50

WB use

human colon tissue were subjected to SDS PAGE followed by western blot with PAab06896(PSME3 antibody) at dilution of 1:500

Protein Information

Gene ID10197

Uniprot ID P61289

Calculated MW

location