Anti-PTBP1 antibody

Product Name Anti-PTBP1 antibody

Catalog No PAab06906

Packing 100ug

Form liquid

Alternative Name PTB

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).

Immunogen polypyrimidine tract binding protein 1

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IF,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human prostate cancer slide using PTBP1 Antibody at dilution of 1:50

WB use

Jurkat cells were subjected to SDS PAGE followed by western blot with PAab06906(PTBP1 antibody) at dilution of 1:400

Protein Information

Gene ID5725

Uniprot ID P26599

Calculated MW

location