Anti-RAD23A antibody
Product Name Anti-RAD23A antibody
Catalog No PAab07077
Packing 100ug
Form liquid
Alternative Name
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.
Immunogen RAD23 homolog A (S. cerevisiae)
Specificity Human, Mouse ,Rat
Tested Application ELISA,WB,IHC,IP
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human lymphoma usingRAD23A antibody at dilution of 1:50
WB use
Jurkat cells were subjected to SDS PAGE followed by western blot with PAab07077(RAD23A antibody) at dilution of 1:500
Protein Information
Gene ID5886
Uniprot ID P54725
Calculated MW
location