Anti-RB1CC1 antibody
Product Name Anti-RB1CC1 antibody
Catalog No PAab07145
Packing 100ug
Form liquid
Alternative Name KIAA0203 antibody, RBICC
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.
Immunogen RB1-inducible coiled-coil 1
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IF,IHC,IP
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human breast cancer usingRB1CC1 antibody at dilution of 1:200
WB use
HeLa cells were subjected to SDS PAGE followed by western blot with PAab07145(RB1CC1 antibody) at dilution of 1:1000
Protein Information
Gene ID9821
Uniprot ID Q8TDY2
Calculated MW
location