Anti-RXRA antibody
Product Name Anti-RXRA antibody
Catalog No PAab07542
Packing 100ug
Form liquid
Alternative Name NR2B1
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
Immunogen retinoid X receptor, alpha
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IF,IHC,IP
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human kidney usingRXRA antibody at dilution of 1:200
WB use
MCF7 cells were subjected to SDS PAGE followed by western blot with PAab07542(RXRA antibody) at dilution of 1:600
Protein Information
Gene ID6256
Uniprot ID P19793
Calculated MW
location