Anti-SHP2 antibody

Product Name Anti-SHP2 antibody

Catalog No PAab07854

Packing 100ug

Form liquid

Alternative Name BPTP3 antibody, CFC antibody, NS1 antibody, PTP 1D antibody, PTP 2C antibody, PTP2C antibody, PTPN11 antibody, SH PTP2 antibody, SH PTP3 antibody, SHP 2 antibody, SHP2 antibody, SHPTP2

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

PTPN11(protein tyrosine phosphatase, non-receptor type 11) is also named as PTP-1D, PTP2, PTP2C, PTP3, SHP2, CFC, CFC, BPTP3, SH-PTP2, SH-PTP3, MGC14433 and belongs to the protein-tyrosine phosphatase family and non-receptor class 2 subfamily. It modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism(PMID:19017799). Its signaling may play equally important roles in retinal survival in both physiological and pathological conditions(PMID:21576358). Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1), Noonan syndrome type 1 (NS1), juvenile myelomonocytic leukemia (JMML) and metachondromatosis (MC). It has 3 isoforms produced by alternative splicing.

Immunogen protein tyrosine phosphatase, non-receptor type 11

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC,IF,IP

Recommended dilution WB:1:500-1:5000;IP:1:500-1:5000;IHC:1:20-1:200;IF:1:10-1:100

IHC use

Immunohistochemistry of paraffin-embedded human breast cancer usingPTPN11 antibody at dilution of 1:100

WB use

Jurkat cells were subjected to SDS PAGE followed by western blot with PAab07854(PTPN11 antibody) at dilution of 1:500

Protein Information

Gene ID5781

Uniprot ID Q06124

Calculated MW 68kDa,observed 68kDa,53kDa

location