Anti-SLC12A5-Specific antibody
Product Name Anti-SLC12A5-Specific antibody
Catalog No PAab07908
Packing 100ug
Form liquid
Alternative Name hKCC2 antibody, K Cl cotransporter 2 antibody, KCC2 antibody, KIAA1176 antibody, Neuronal K Cl cotransporter antibody, SLC12A5
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl- cotransporter that is essential for Cl- homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect ~130 kda monomer and ~250 kDa dimer of KKC2 in brain lysate.
Immunogen solute carrier family 12 (potassium-chloride transporter), member 5
Specificity Human, Mouse ,Rat
Tested Application ELISA,WB,IHC
Recommended dilution WB : 1:500-1:5000 IHC : 1:20-1:200
IHC use
Immunohistochemistry of paraffin-embedded human brain usingSLC12A5-Specific antibody at dilution of 1:100
WB use
human brain tissue were subjected to SDS PAGE followed by western blot with PAab07908(SLC12A5-Specific antibody) at dilution of 1:300
Protein Information
Gene ID
Uniprot ID Q9H2X9
Calculated MW 126 kDa
location