Anti-SLC12A5-Specific antibody

Product Name Anti-SLC12A5-Specific antibody

Catalog No PAab07908

Packing 100ug

Form liquid

Alternative Name hKCC2 antibody, K Cl cotransporter 2 antibody, KCC2 antibody, KIAA1176 antibody, Neuronal K Cl cotransporter antibody, SLC12A5

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl- cotransporter that is essential for Cl- homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect ~130 kda monomer and ~250 kDa dimer of KKC2 in brain lysate.

Immunogen solute carrier family 12 (potassium-chloride transporter), member 5

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB,IHC

Recommended dilution WB : 1:500-1:5000 IHC : 1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human brain usingSLC12A5-Specific antibody at dilution of 1:100

WB use

human brain tissue were subjected to SDS PAGE followed by western blot with PAab07908(SLC12A5-Specific antibody) at dilution of 1:300

Protein Information

Gene ID

Uniprot ID Q9H2X9

Calculated MW 126 kDa

location