Anti-SMAD7 antibody

Product Name Anti-SMAD7 antibody

Catalog No PAab07999

Packing 100ug

Form liquid

Alternative Name MADH7 antibody, MADH8

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).

Immunogen SMAD family member 7

Specificity Human, Mouse

Tested Application ELISA,WB

Recommended dilution

IHC use

WB use

Protein Information

Gene ID4092

Uniprot ID O15105

Calculated MW

location