Product Name Anti-TEX14 antibody
Catalog No PAab08609
Packing 100ug
Form liquid
Alternative Name SGK307
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).
Immunogen testis expressed 14
Specificity Human, Mouse
Tested Application ELISA,WB,IHC,IP
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human testis usingTEX14 antibody at dilution of 1:50
WB use
mouse testis tissue were subjected to SDS PAGE followed by western blot with PAab08609(TEX14 antibody) at dilution of 1:500
Protein Information
Gene ID56155
Uniprot ID Q8IWB6
Calculated MW
location
English
