Anti-TICAM2 antibody

Product Name Anti-TICAM2 antibody

Catalog No PAab08687

Packing 100ug

Form liquid

Alternative Name TIRAP3 antibody, TIRP antibody, TRAM

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

Immunogen toll-like receptor adaptor molecule 2

Specificity Human

Tested Application ELISA,WB,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human testis tissue slide using TICAM2 Antibody at dilution of 1:50

WB use

PC-3 cells were subjected to SDS PAGE followed by western blot with PAab08687(TICAM2 antibody) at dilution of 1:500

Protein Information

Gene ID353376

Uniprot ID Q86XR7

Calculated MW

location