Anti-TSEN2 antibody

Product Name Anti-TSEN2 antibody

Catalog No PAab09038

Packing 100ug

Form liquid

Alternative Name HsSen2 antibody, PCH2B antibody, SEN2 antibody, SEN2L antibody, tRNA intron endonuclease Sen2 antibody, TSEN2

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre- mRNA 3'-end processing factors, establishing a link between pre- tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

Immunogen tRNA splicing endonuclease 2 homolog (S. cerevisiae)

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB

Recommended dilution WB:1:500-1:5000

IHC use

WB use

human brain tissue were subjected to SDS PAGE followed by western blot with PAab09038(TSEN2 antibody) at dilution of 1:400

Protein Information

Gene ID80746

Uniprot ID Q8NCE0

Calculated MW 51kDa

location